HYPERPROLACTINEMIA

Cabergoline 0.25/0.5 mg

Top 10 Hyperprolactinemia Medicine in India

Top 10 Hyperprolactinemia Medicine in India- Hyperprolactinemia is a medical term that refers to an abnormally high concentration of prolactin in the blood. Prolactin is a hormone that is produced by the pituitary gland, which is essential for breast milk production. However, excessively high levels of prolactin can cause reproductive health problems like infertility, amenorrhea in females, impotence, and low sexual drive in men. In India when patients are diagnosed with hyperprolactinemia, mainly dopaminergic medications are prescribed to control the levels of prolactin hormone in the blood. The degree of severity of the condition and the patient’s personal preferences also determine how the treatment is administered.
Below is the list of the ten most effective drugs for the treatment of hyperprolactinemia in India along with their constituents, and working style.

1. Cabergoline

Active ingredient: Cabergoline
Cabergoline is a dopamine receptor agonist and is the drug of choice in cases of hyperprolactinemia. It acts on dopaminergic receptors in the central nervous system, leading to inhibition of prolactin release from the pituitary gland. Due to a longer half-life, cabergoline can be dosed once every two weeks thereby enhancing patient compliance.
Frequent Adverse Effects:

Nausea
Dizziness
Tiredness

Brand Name-

Ryon Pharma

2. Bromocriptine

Active Ingredient: Bromocriptine Mesylate
Similar to cabergoline, bromocriptine is a dopamine receptor agonist, which blocks the release of prolactin. It is usually given to patients who are intolerant to cabergoline. Due to the shorter half-life of bromocriptine, it is necessary to administer it daily.
Most Frequently Occurring Adverse Reactions:

Vomiting
Orthostatic hypotension
Migrant headache

3. Quinagolide

Composition: Hydrochloride of quinagolide
Quinagolide is a non-ergot dopamine agonist approved for the treatment of hyperprolactinemia. It is unique from other dopamine agonists because it is not derived from ergot alkaloids hence patients who do not tolerate ergot-based drugs can still use this medication.
Typical Side Effects:

Nausea
Dizziness
Abdominal pain

4. Pergolide

Composition: Mesylate of Pergolide
Pergolide is another agent belonging to the class of dopamine agonists, also used like cabergoline and bromocriptine. It is not used due to the risk of heart valve damage but it can be given if other mechanisms fail.
Common Side Effects:

Hallucinations
Disturbances in Sleep
Somnolence

5. Levodopa

Composition: Levodopa
Levodopa primarily treats Parkinson's Disease but has also been found to lower prolactin levels in certain individuals. This is due to an increase in serotonin levels in the brain which inhibits the release of prolactin.
Common Side Effects:

Nausea
Disorientation
Wave-like movements of the body are also known as Dyskinesia.

6. Selegiline

Composition: Selegiline Hydrochloride
Selegiline is a selective monoamine oxidase B (MAO-B) enzyme inhibitor used for the management of patients with Parkinson’s disease. In addition, its effect on the amount of dopamine has proven useful in addressing hyperprolactinemia. This is because selegiline inhibits dopamine breakdown which consequently results in reduced concentrations of prolactin.
Common Side Effects:

Light-headedness
Lack of sleep
Stomach upset

7. Amantadine

Composition: Amantadine Hydrochloride
Another medication that has shown a considerable effect on the reduction of prolactin levels is Amantadine, which is primarily used in the management of Parkinson’s disease. It is accomplished by encouraging the leakage of dopamine and negating the action of the dopamine transporters, thus controlling the levels of prolactin.
Common Side Effects:

Nausea
swelling of limbs
sleep disorder

8. Pramipexole-

Composition: Pramipexole Dihydrochloride
Pramipexole is classified as a non-ergot dopamine agonist and is frequently given to patients for the management of Parkinson’s disease and hyperprolactinemia. It binds to particular types of dopamine receptors and thus decreases the amount of prolactin released from the pituitary gland. It is usually reserved for patients who cannot tolerate drugs that are derived from ergot alkaloids.
Common Side Effects:

Weakness Suppression of blood pressure ward sleeping In this sleeping disorder suppression of blood pressure occurs while the patient is actively present.

9. Ropinirole

Ingredients: Ropinirole Hydrochloride
Ropinirole is also prescribed as a hyperprolactinemia and Parkinson’s disease remedy being a non-ergot dopamine agonist. Its action on dopamine receptors actively controls the levels of prolactin hormone thus effective for hyperprolactinemia.
Common Side Effects:

Nausea
Dizziness
Drowsiness

10. Domperidone

Composition: Domperidone
Domperidone is notable as a dopamine antagonist to primarily controls nausea and/or other gastrointestinal disturbances. However, the use of domperidone paradoxically promotes the elevation of PRL levels. Domperidone is however used in some instances where stimulants are employed alongside other medications to counteract the nausea without disrupting the control of prolactin. Dosages of domperidone hydrochloride.
Common Side Effects:

Dry mouth
Abdominal cramps
Headache

Conclusion-

Management of hyperprolactinemia primarily depends on the use of dopamine agonists such as cabergoline and bromocriptine, which have been proven to reduce prolactin levels and shrink prolactinomas. In new medications like quinagolide and pramipexole, alternatives are provided for those patients who cannot tolerate the conventional ones. Each of these medicines is available in India under various brand names and is selected according to individual patient response and tolerability. norgepar.com Furthermore, if hyperprolactinemia has been established in you, you must visit a doctor to find out how to achieve the results without experiencing unpleasant effects.

FAQ’S About Top 10 Hyperprolactinemia Medicine

1. What is hyperprolactinemia and what is its treatment in India?
Hyperprolactinemia refers to a female hyperprolactinemic syndrome that is associated with increased prolactin levels in the blood, which causes menstrual irregularities, infertility, and galactorrhea. In most cases, however, the treatment in India consists of treatment mainly with dopamine agonists such as (Cabergoline and Bromocriptine) which lower the prolactin level.
2. What are the top hyperprolactinemia medications available in India?
The most commonly used hyperprolactinemia medications in India are Cabergoline (Dostinex. Cabgolin), and Bromocriptine (Parlodel). They both effectively reduce prolactin levels and can be obtained from pharma distributors in India. These medications are usually given by endocrinologists and gynecologists.
3. What is the market demand for hyperprolactinemia medicines in India?
There is rising market demand for drugs used in the treatment of hyperprolactinemia in India, owing to the growing popularity of reproductive health and the increasing incidence of such conditions associated with hormonal issues.